A database of hormones and their receptors |
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HMRbase accession number | 20035 |
Swiss-prot Accession number | Q2Q421 (Sequence in FASTA format) |
Description | EGF-like module-containing mucin-like hormone receptor-like 2precursor (EGF-like module EMR2) (CD312 antigen). |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Membrane; multi-pass membrane protein |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 5 EGF-like domains. Contains 1 GPS domain. |
Tissue Specificity | N/A |
Post translational modification | Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit (By similarity). |
Function | Receptor probably involved in cell attachment (By similarity). |
Protein Length | 830 Amino acids |
Molecular weight | 91452 |
Domain Name | 7tm_2 EGF_CA GPS EGF |
References | 1 Kwakkenbos M.J., Matmati M., Pouwels W., Wang Y., Bontrop R.E.,Heidt P.J., Hoek R.M., Hamann J.; "A unique mode of concerted evolution of the EGF-TM7 receptor chimeraEMR2."; Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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Hormone | N/A |
Gene ID | 610750 |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
HMRbase accession number | 20051 |
Swiss-prot Accession number | Q9MZI6 (Sequence in FASTA format) |
Description | Gonadotropin-releasing hormone receptor (GnRH receptor) (GnRH-R). |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Membrane; multi-pass membrane protein |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 1 family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Receptor for gonadotropin releasing hormone (GnRH) that mediate the action of GnRH to stimulate the secretion of the gonadotropic hormones (LH and FSH). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
Protein Length | 327 Amino acids |
Molecular weight | 37656 |
Domain Name | 7tm_1 |
References | 1 PubMed abstract 10809231 |
Hormone | N/A |
Gene ID | 403718 |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
HMRbase accession number | 20289 |
Swiss-prot Accession number | Q6XXX9 (Sequence in FASTA format) |
Description | 5-hydroxytryptamine 1A receptor (5-HT-1A) (Serotonin receptor 1A) (5-HT1A). |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Cell membrane; multi-pass membrane protein |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 1 family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity (By similarity). |
Protein Length | 423 Amino acids |
Molecular weight | 46356 |
Domain Name | 7tm_1 |
References | 1 PubMed abstract 15220384 |
Hormone | N/A |
Gene ID | 487230 |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
HMRbase accession number | 20297 |
Swiss-prot Accession number | P79250 (Sequence in FASTA format) |
Description | 5-hydroxytryptamine 1B receptor (5-HT-1B) (Serotonin receptor 1B) (5-HT1B) (5-HTR1B) (5-HT1D subtype beta). |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Cell membrane; multi-pass membrane protein |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 1 family. |
Tissue Specificity | N/A |
Post translational modification | Phosphorylated (By similarity). Palmitoylated (By similarity). |
Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. |
Protein Length | 389 Amino acids |
Molecular weight | 42930 |
Domain Name | 7tm_1 |
References | 1 PubMed abstract 14729271 2 PubMed abstract 15353848 3 PubMed abstract 15220384 4 PubMed abstract 8763409 |
Hormone | N/A |
Gene ID | 403741 |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
HMRbase accession number | 20310 |
Swiss-prot Accession number | P11614 (Sequence in FASTA format) |
Description | 5-hydroxytryptamine 1D receptor (5-HT-1D) (Serotonin receptor 1D). |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Cell membrane; multi-pass membrane protein |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 1 family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. |
Protein Length | 377 Amino acids |
Molecular weight | 41883 |
Domain Name | 7tm_1 |
References | 1 PubMed abstract 2541503 2 PubMed abstract 2159630 3 PubMed abstract 1659418 4 PubMed abstract 1758439 |
Hormone | N/A |
Gene ID | 403963 |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
HMRbase accession number | 20324 |
Swiss-prot Accession number | O46635 (Sequence in FASTA format) |
Description | 5-hydroxytryptamine 2A receptor (5-HT-2A) (Serotonin receptor 2A) (5-HT-2) (5-hydroxytryptamine receptor). |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Cell membrane; multi-pass membrane protein (By similarity). Note=Localizes to the post-synaptic thickening of axo-dendritic synapses (By similarity) |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 1 family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production (By similarity). |
Protein Length | 470 Amino acids |
Molecular weight | 52378 |
Domain Name | 7tm_1 |
References | 1 PubMed abstract 15353848 2 PubMed abstract 15862800 3 Sgard F.; Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases. |
Hormone | N/A |
Gene ID | 403882 |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
HMRbase accession number | 20337 |
Swiss-prot Accession number | Q60F97 (Sequence in FASTA format) |
Description | 5-hydroxytryptamine 2C receptor (5-HT-2C) (Serotonin receptor 2C) (5-HT2C) (5-HTR2C). |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Cell membrane; multi-pass membrane protein (By similarity) |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 1 family. |
Tissue Specificity | N/A |
Post translational modification | N-glycosylated (By similarity). |
Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). |
Protein Length | 458 Amino acids |
Molecular weight | 51836 |
Domain Name | 7tm_1 |
References | 1 PubMed abstract 15353848 |
Hormone | N/A |
Gene ID | 450240 |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
HMRbase accession number | 20380 |
Swiss-prot Accession number | Q50DZ8 (Sequence in FASTA format) |
Description | Serotonin 5HT2B receptor. |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Membrane (By similarity) |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 1 family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). |
Protein Length | 434 Amino acids |
Molecular weight | 49051 |
Domain Name | 7tm_1 |
References | 1 PubMed abstract 15862800 |
Hormone | N/A |
Gene ID | 403881 |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
HMRbase accession number | 20412 |
Swiss-prot Accession number | Q8HYB0 (Sequence in FASTA format) |
Description | Serotonin receptor 1A. |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Membrane (By similarity) |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 1 family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity (By similarity). |
Protein Length | 423 Amino acids |
Molecular weight | 46399 |
Domain Name | 7tm_1 |
References | 1 PubMed abstract 12692162 2 PubMed abstract 16251523 |
Hormone | N/A |
Gene ID | N/A |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
HMRbase accession number | 20591 |
Swiss-prot Accession number | Q4L144 (Sequence in FASTA format) |
Description | Somatostatin receptor subtype 3. |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Membrane (By similarity) |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 1 family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | N/A |
Protein Length | 425 Amino acids |
Molecular weight | 45961 |
Domain Name | 7tm_1 |
References | 1 Liew C.W., Richter D., Kreienkamp H.-J.; "Interaction of human SSTR3 receptor with tight junction protein,MUPP1, via PDZ domain."; Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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Hormone | N/A |
Gene ID | 481272 |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
HMRbase accession number | 20778 |
Swiss-prot Accession number | P79148 (Sequence in FASTA format) |
Description | Beta-1 adrenergic receptor (Beta-1 adrenoceptor) (Beta-1adrenoreceptor). |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Cell membrane; multi-pass membrane protein (By similarity). Note=Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression (By similarity) |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 1 family. |
Tissue Specificity | N/A |
Post translational modification | Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase (By similarity). |
Function | Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. |
Protein Length | 473 Amino acids |
Molecular weight | 50061 |
Domain Name | 7tm_1 |
References | 1 PubMed abstract 9220370 |
Hormone | N/A |
Gene ID | 493972 |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
HMRbase accession number | 20788 |
Swiss-prot Accession number | P54833 (Sequence in FASTA format) |
Description | Beta-2 adrenergic receptor (Beta-2 adrenoceptor) (Beta-2adrenoreceptor). |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Cell membrane; multi-pass membrane protein |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 1 family. |
Tissue Specificity | N/A |
Post translational modification | Palmitoylated; may reduce accessibility of Ser-345 and Ser- 346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation (By similarity). Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA- mediated phosphorylation seems to facilitate phosphorylation by BARK (By similarity). |
Function | Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. |
Protein Length | 415 Amino acids |
Molecular weight | 46589 |
Domain Name | 7tm_1 |
References | 1 PubMed abstract 8880434 2 PubMed abstract 9220370 |
Hormone | N/A |
Gene ID | 403910 |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
HMRbase accession number | 20798 |
Swiss-prot Accession number | O02662 (Sequence in FASTA format) |
Description | Beta-3 adrenergic receptor (Beta-3 adrenoceptor) (Beta-3adrenoreceptor). |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Cell membrane; multi-pass membrane protein |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 1 family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis. |
Protein Length | 405 Amino acids |
Molecular weight | 43051 |
Domain Name | 7tm_1 |
References | 1 PubMed abstract 9881593 2 Thompson G.M., Kelly L.J., Candelore M.R.; Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases. |
Hormone | N/A |
Gene ID | 442979 |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
HMRbase accession number | 20866 |
Swiss-prot Accession number | O77808 (Sequence in FASTA format) |
Description | Vasopressin V2 receptor (Renal-type arginine vasopressin receptor)(Antidiuretic hormone receptor) (AVPR V2). |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Membrane; multi-pass membrane protein |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 1 family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). |
Protein Length | 370 Amino acids |
Molecular weight | 40200 |
Domain Name | 7tm_1 |
References | 1 Weber B.I.L., Rascher W.; Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
2 Weber B.I.L., Rascher W.; "Organization of the dog vasopressin receptor gene."; Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases. 3 Weber B.I.L., Rascher W.; Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases. 4 Weber B.I.L., Rascher W.; "Organization of the dog vasopressin receptor gene."; Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases. |
Hormone | N/A |
Gene ID | 403804 |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
HMRbase accession number | 20890 |
Swiss-prot Accession number | O77616 (Sequence in FASTA format) |
Description | Melanocyte-stimulating hormone receptor (MSH-R) (Melanotropinreceptor) (Melanocortin receptor 1) (MC1-R). |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Membrane; multi-pass membrane protein |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 1 family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Could be involved in spermatogenesis. |
Protein Length | 317 Amino acids |
Molecular weight | 34984 |
Domain Name | 7tm_1 |
References | 1 PubMed abstract 10895310 2 PubMed abstract 10895310 |
Hormone | N/A |
Gene ID | 489652 |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
HMRbase accession number | 20954 |
Swiss-prot Accession number | Q5D0K2 (Sequence in FASTA format) |
Description | Cholecystokinin type A receptor (CCK-A receptor) (CCK-AR)(Cholecystokinin-1 receptor) (CCK1-R). |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Cell membrane; multi-pass membrane protein |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 1 family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). |
Protein Length | 428 Amino acids |
Molecular weight | 47836 |
Domain Name | N/A |
References | 1 PubMed abstract 15765098 2 PubMed abstract 15765098 |
Hormone | N/A |
Gene ID | 488846 |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
HMRbase accession number | 20981 |
Swiss-prot Accession number | P14763 (Sequence in FASTA format) |
Description | Thyrotropin receptor precursor (TSH-R) (Thyroid-stimulating hormonereceptor). |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Membrane; multi-pass membrane protein |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. Contains 4 LRR (leucine-rich) repeats. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5). |
Protein Length | 764 Amino acids |
Molecular weight | 86483 |
Domain Name | 7tm_1 LRR_1 |
References | 1 PubMed abstract 2602159 2 PubMed abstract 2556796 |
Hormone | P54828 Detail in HMRbase Q9XSW8 Detail in HMRbase |
Gene ID | 403968 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 21005 |
Swiss-prot Accession number | P30552 (Sequence in FASTA format) |
Description | Gastrin/cholecystokinin type B receptor (CCK-B receptor) (CCK-BR)(Cholecystokinin-2 receptor) (CCK2-R). |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Cell membrane; multi-pass membrane protein |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 1 family. |
Tissue Specificity | Parietal cells, pancreas, brain and various neoplastic tissues. |
Post translational modification | N/A |
Function | Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
Protein Length | 453 Amino acids |
Molecular weight | 48519 |
Domain Name | 7tm_1 |
References | 1 PubMed abstract 1373504 2 Song I., Blandizzi C., Brown D.R., Kang D.H., Todisco A., Delvalle J.,del Tacca M., Owyang C., Yamada T.; "Molecular cloning and structural analysis of the canine gastrin/CCK-Breceptor gene."; Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases. 3 PubMed abstract 1373504 4 Song I., Blandizzi C., Brown D.R., Kang D.H., Todisco A., Delvalle J.,del Tacca M., Owyang C., Yamada T.; "Molecular cloning and structural analysis of the canine gastrin/CCK-Breceptor gene."; Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases. |
Hormone | P01353 Detail in HMRbase |
Gene ID | N/A |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 21091 |
Swiss-prot Accession number | Q49LX5 (Sequence in FASTA format) |
Description | Somatostatin receptor type 1 (SS1R). |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Cell membrane; multi-pass membrane protein (By similarity) |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 1 family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins (By similarity). |
Protein Length | 391 Amino acids |
Molecular weight | 42670 |
Domain Name | 7tm_1 |
References | 1 Liew C.W., Richter D., Kreienkamp H.-J.; "Cloning of somatostatin receptors from Canis familiaris."; Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
2 Liew C.W., Richter D., Kreienkamp H.-J.; "Cloning of somatostatin receptors from Canis familiaris."; Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases. |
Hormone | P49670 Detail in HMRbase |
Gene ID | 403455 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 21092 |
Swiss-prot Accession number | Q49LX6 (Sequence in FASTA format) |
Description | Somatostatin receptor type 2 (SS2R). |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Cell membrane; multi-pass membrane protein (By similarity) |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 1 family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels (By similarity). |
Protein Length | 369 Amino acids |
Molecular weight | 41293 |
Domain Name | 7tm_1 |
References | 1 Liew C.W., Richter D., Kreienkamp H.-J.; "Cloning of somatostatin receptors from Canis familiaris."; Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
2 Liew C.W., Richter D., Kreienkamp H.-J.; "Cloning of somatostatin receptors from Canis familiaris."; Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases. |
Hormone | P49670 Detail in HMRbase |
Gene ID | 403472 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 21106 |
Swiss-prot Accession number | Q5XM32 (Sequence in FASTA format) |
Description | Relaxin receptor 2 (Relaxin family peptide receptor 2) (Leucine-richrepeat-containing G-protein coupled receptor 8) (INSL3 receptor). |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Cell membrane; Multi-pass membrane protein |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 1 family. Contains 1 LDL-receptor class A domain. Contains 10 LRR (leucine-rich) repeats. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (By similarity). |
Protein Length | 737 Amino acids |
Molecular weight | 84109 |
Domain Name | LRR_1 7tm_1 Ldl_recept_a |
References | 1 Agoulnik A.I.; Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
|
Hormone | Q9TRM8 Detail in HMRbase |
Gene ID | 450220 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 21151 |
Swiss-prot Accession number | Q8MIP5 (Sequence in FASTA format) |
Description | Melanin-concentrating hormone receptor subtype 2. |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Membrane (By similarity) |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 1 family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | N/A |
Protein Length | 330 Amino acids |
Molecular weight | 37759 |
Domain Name | 7tm_1 |
References | 1 Tan C.P., Sano H., Iwaasa H., Pan J., Sailer A., Hreniuk D.L.,Feighner S.D., Palyha O.C., Figueroa D.J., Austin C.P., Jiang M.M.,Yu H., Ito J., Ito M., Ito M., Guan X.M., Kanatani A.,Van der Ploeg L.H.T., Howard A.D.; "Melanin-Concentrating Hormone Receptor Subtypes 1 and 2: SpeciesSpecific Gene Expression."; Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
|
Hormone | Q5XXR2 Detail in HMRbase |
Gene ID | 403562 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 21152 |
Swiss-prot Accession number | Q8MIP6 (Sequence in FASTA format) |
Description | Melanin-concentrating hormone receptor subtype 1. |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Membrane; multi-pass membrane protein (By similarity). |
Developmental Stage | N/A |
Similarity | N/A |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | N/A |
Protein Length | 353 Amino acids |
Molecular weight | 39064 |
Domain Name | 7tm_1 |
References | 1 Tan C.P., Sano H., Iwaasa H., Pan J., Sailer A., Hreniuk D.L.,Feighner S.D., Palyha O.C., Figueroa D.J., Austin C.P., Jiang M.M.,Yu H., Ito J., Ito M., Ito M., Guan X.M., Kanatani A.,Van der Ploeg L.H.T., Howard A.D.; "Melanin-Concentrating Hormone Receptor Subtypes 1 and 2: SpeciesSpecific Gene Expression."; Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
|
Hormone | Q5XXR2 Detail in HMRbase |
Gene ID | 403563 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 21199 |
Swiss-prot Accession number | Q9TU31 (Sequence in FASTA format) |
Description | Parathyroid hormone/parathyroid hormone-related peptide receptorprecursor (PTH/PTHr receptor) (PTH/PTHrP type I receptor). |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Membrane; multi-pass membrane protein |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 2 family. |
Tissue Specificity | High levels in the kidney, with much lower levels in aorta, heart, lung, prostate, testis, and skeletal muscle. |
Post translational modification | N/A |
Function | This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system (By similarity). |
Protein Length | 595 Amino acids |
Molecular weight | 66309 |
Domain Name | 7tm_2 HRM |
References | 1 PubMed abstract 12153143 2 PubMed abstract 12153143 |
Hormone | P52212 Detail in HMRbase |
Gene ID | 403779 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 21200 |
Swiss-prot Accession number | Q9TU69 (Sequence in FASTA format) |
Description | Growth hormone receptor precursor (GH receptor) (Somatotropinreceptor) [Contains: Growth hormone-binding protein (GH-bindingprotein) (GHBP) (Serum-binding protein)]. |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Cell membrane; single-pass type I membrane protein (By similarity). Note=On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway (By similarity) |
Developmental Stage | N/A |
Similarity | Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 1 fibronectin type-III domain. |
Tissue Specificity | Expressed in normal and tumorous mammary tissues, being localized in epithelial and myoepithelial/spindle cell components and in the activated fibroblasts of desmoplastic tumor stroma. Isoform 1, isoform 2 and isoform 3 are found in both normal and tumorous mammary tissues, isoform 1 being the predomiant isoform. Isoform 1, isoform 3, isoform 4 and isoform 5 are expressed in the CMT-U335 cell line. |
Post translational modification | On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2 (By similarity). On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization (By similarity). |
Function | Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling (By similarity). |
Protein Length | 638 Amino acids |
Molecular weight | 71041 |
Domain Name | N/A |
References | 1 PubMed abstract 10579357 2 PubMed abstract 8894053 |
Hormone | P33711 Detail in HMRbase |
Gene ID | 403721 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 21207 |
Swiss-prot Accession number | Q9TT90 (Sequence in FASTA format) |
Description | RecName: Androgen receptor;Alternative Name: Dihydrotestosterone receptor;Alternative Name: Nuclear receptor subfamily 3 group C member 4; |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Nucleus (By similarity) |
Developmental Stage | N/A |
Similarity | Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
Tissue Specificity | N/A |
Post translational modification | Phosphorylated in prostate cancer cells in response to several growth factors including EGF. Phosphorylation is induced by c-Src kinase (CSK). Tyr-522 is one of the major phosphorylation sites and an increase in phosphorylation and Src kinase activity is associated with prostate cancer progression (By similarity). |
Function | Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 (By similarity). |
Protein Length | 907 Amino acids |
Molecular weight | 98727 |
Domain Name | Androgen_recep Hormone_recep zf-C4 |
References | 1 PubMed abstract 11768233 |
Hormone | Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase |
Gene ID | 403588 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 21243 |
Swiss-prot Accession number | Q6QMY5 (Sequence in FASTA format) |
Description | RecName: Steroid hormone receptor ERR1;Alternative Name: Estrogen-related receptor, alpha;ERR-alpha;Alternative Name: Nuclear receptor subfamily 3 group B member 1; |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Nucleus (By similarity) |
Developmental Stage | N/A |
Similarity | Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
Tissue Specificity | N/A |
Post translational modification | Phosphorylated (Probable). |
Function | Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. May function as a modulator of the estrogen signaling pathway in the uterus (By similarity). |
Protein Length | 422 Amino acids |
Molecular weight | 45457 |
Domain Name | Hormone_recep zf-C4 |
References | ---- |
Hormone | N/A |
Gene ID | 403169 |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
HMRbase accession number | 21396 |
Swiss-prot Accession number | P51666 (Sequence in FASTA format) |
Description | Nuclear receptor subfamily 4 group A member 1;Alternative Name: Orphan nuclear receptor HMR;Alternative Name: Orphan nuclear receptor NGFI-B |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Nucleus |
Developmental Stage | N/A |
Similarity | Belongs to the nuclear hormone receptor family. NR4 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Orphan nuclear receptor. |
Protein Length | 598 Amino acids |
Molecular weight | 64424 |
Domain Name | Hormone_recep zf-C4 |
References | 1 PubMed abstract 8895335 |
Hormone | N/A |
Gene ID | 403897 |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
HMRbase accession number | 21416 |
Swiss-prot Accession number | Q95N78 (Sequence in FASTA format) |
Description | Peroxisome proliferator-activated receptor alpha;PPAR-alpha;Alternative Name: Nuclear receptor subfamily 1 group C member 1 |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Nucleus |
Developmental Stage | N/A |
Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids (By similarity). |
Protein Length | 468 Amino acids |
Molecular weight | 52123 |
Domain Name | Hormone_recep zf-C4 |
References | ---- |
Hormone | Detail in HMRbase Detail in HMRbase |
Gene ID | 403654 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 21423 |
Swiss-prot Accession number | Q0ZAQ8 (Sequence in FASTA format) |
Description | Peroxisome proliferator-activated receptor delta;PPAR-delta;Alternative Name: PPAR-beta;Alternative Name: Nuclear receptor subfamily 1 group C member 2 |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Nucleus (By similarity) |
Developmental Stage | N/A |
Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Decreases expression of NPC1L1 once activated by a ligand (By similarity). |
Protein Length | 441 Amino acids |
Molecular weight | 49776 |
Domain Name | Hormone_recep zf-C4 |
References | ---- |
Hormone | Detail in HMRbase |
Gene ID | 481756 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 21426 |
Swiss-prot Accession number | Q4U3Q4 (Sequence in FASTA format) |
Description | Peroxisome proliferator-activated receptor gamma;PPAR-gamma;Alternative Name: Nuclear receptor subfamily 1 group C member 3 |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Nucleus (By similarity) |
Developmental Stage | N/A |
Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis (By similarity). |
Protein Length | 505 Amino acids |
Molecular weight | 57511 |
Domain Name | Hormone_recep zf-C4 |
References | ---- |
Hormone | Detail in HMRbase |
Gene ID | 403606 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 21435 |
Swiss-prot Accession number | Q9GLW0 (Sequence in FASTA format) |
Description | Progesterone receptor;PR;Alternative Name: Nuclear receptor subfamily 3 group C member 3 |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Nucleus. Note=Diverse nuclear localization patterns of PR observed in tumorous mammary and uterine tissue, including strong nuclear or perinuclear localization, heterogeneous expression or complete lack of expression, depending on tumor type and stage |
Developmental Stage | N/A |
Similarity | Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
Tissue Specificity | Expressed in mammary gland and uterus. |
Post translational modification | N/A |
Function | The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. |
Protein Length | 939 Amino acids |
Molecular weight | 98418 |
Domain Name | Hormone_recep Prog_receptor zf-C4 |
References | 1 PubMed abstract 11282275 |
Hormone | Detail in HMRbase Detail in HMRbase |
Gene ID | 403621 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 21446 |
Swiss-prot Accession number | Q5FBR4 (Sequence in FASTA format) |
Description | Retinoic acid receptor alpha;RAR-alpha;Alternative Name: Nuclear receptor subfamily 1 group B member 1 |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Nucleus (By similarity) |
Developmental Stage | N/A |
Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | This is a receptor for retinoic acid. This metabolite has profound effects on vertebrate development. Retinoic acid is a morphogen and is a powerful teratogen. This receptor controls cell function by directly regulating gene expression (By similarity). |
Protein Length | 462 Amino acids |
Molecular weight | 50771 |
Domain Name | Hormone_recep zf-C4 |
References | ---- |
Hormone | N/A |
Gene ID | 480526 |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
HMRbase accession number | 21480 |
Swiss-prot Accession number | Q5TJF7 (Sequence in FASTA format) |
Description | Retinoic acid receptor RXR-beta;Alternative Name: Retinoid X receptor beta;Alternative Name: Nuclear receptor subfamily 2 group B member 2 |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Nucleus (By similarity) |
Developmental Stage | N/A |
Similarity | Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA) (By similarity). |
Protein Length | 533 Amino acids |
Molecular weight | 56917 |
Domain Name | Hormone_recep zf-C4 |
References | 1 PubMed abstract 15607421 |
Hormone | N/A |
Gene ID | N/A |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
HMRbase accession number | 22020 |
Swiss-prot Accession number | Q5TJF8 (Sequence in FASTA format) |
Description | Retinoid X receptor beta; Fragment |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Nucleus |
Developmental Stage | N/A |
Similarity | Belongs to the nuclear hormone receptor family. Contains 1 nuclear receptor DNA-binding domain. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | N/A |
Protein Length | 458 Amino acids |
Molecular weight | 49004 |
Domain Name | Hormone_recep zf-C4 |
References | ---- |
Hormone | N/A |
Gene ID | N/A |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
HMRbase accession number | 22021 |
Swiss-prot Accession number | Q5TJF9 (Sequence in FASTA format) |
Description | Retinoid X receptor beta; Fragment |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Nucleus |
Developmental Stage | N/A |
Similarity | Contains 1 nuclear receptor DNA-binding domain. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | N/A |
Protein Length | 92 Amino acids |
Molecular weight | 10337 |
Domain Name | Hormone_recep |
References | ---- |
Hormone | N/A |
Gene ID | N/A |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
HMRbase accession number | 22340 |
Swiss-prot Accession number | Q864V2 (Sequence in FASTA format) |
Description | Estrogen receptor beta; Fragment |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | N/A |
Developmental Stage | N/A |
Similarity | Belongs to the nuclear hormone receptor family. Contains 1 nuclear receptor DNA-binding domain. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | N/A |
Protein Length | 134 Amino acids |
Molecular weight | 14583 |
Domain Name | zf-C4 |
References | 1 PubMed abstract 12873744 |
Hormone | Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase |
Gene ID | N/A |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 22512 |
Swiss-prot Accession number | Q8SQ02 (Sequence in FASTA format) |
Description | Pregnane X receptor; Fragment |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | N/A |
Developmental Stage | N/A |
Similarity | N/A |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | N/A |
Protein Length | 329 Amino acids |
Molecular weight | 37479 |
Domain Name | Hormone_recep |
References | 1 PubMed abstract 11981033 |
Hormone | Detail in HMRbase Detail in HMRbase Detail in HMRbase |
Gene ID | N/A |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 22542 |
Swiss-prot Accession number | Q8WMS4 (Sequence in FASTA format) |
Description | Peroxisome proliferator-activated receptor-gamma; Fragment |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | N/A |
Developmental Stage | N/A |
Similarity | N/A |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | N/A |
Protein Length | 216 Amino acids |
Molecular weight | 24622 |
Domain Name | Hormone_recep |
References | 1 PubMed abstract 15522994 |
Hormone | Detail in HMRbase |
Gene ID | N/A |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 22629 |
Swiss-prot Accession number | Q95JC0 (Sequence in FASTA format) |
Description | ERbeta protein; Fragment |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | N/A |
Developmental Stage | N/A |
Similarity | Belongs to the nuclear hormone receptor family. Contains 1 nuclear receptor DNA-binding domain. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | N/A |
Protein Length | 250 Amino acids |
Molecular weight | 28073 |
Domain Name | Hormone_recep zf-C4 |
References | ---- |
Hormone | N/A |
Gene ID | N/A |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
HMRbase accession number | 22630 |
Swiss-prot Accession number | Q95JC1 (Sequence in FASTA format) |
Description | ERalpha protein; Fragment |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | N/A |
Developmental Stage | N/A |
Similarity | Belongs to the nuclear hormone receptor family. Contains 1 nuclear receptor DNA-binding domain. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | N/A |
Protein Length | 249 Amino acids |
Molecular weight | 27919 |
Domain Name | Oest_recep zf-C4 |
References | ---- |
Hormone | N/A |
Gene ID | N/A |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
HMRbase accession number | 22919 |
Swiss-prot Accession number | Q9XSB2 (Sequence in FASTA format) |
Description | Thyroid hormone receptor alpha2; Fragment |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | N/A |
Developmental Stage | N/A |
Similarity | N/A |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | N/A |
Protein Length | 60 Amino acids |
Molecular weight | 6522 |
Domain Name | N/A |
References | 1 PubMed abstract 10407478 |
Hormone | N/A |
Gene ID | N/A |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
HMRbase accession number | 22920 |
Swiss-prot Accession number | Q9XSB3 (Sequence in FASTA format) |
Description | Thyroid hormone receptor beta1; Fragment |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | N/A |
Developmental Stage | N/A |
Similarity | N/A |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | N/A |
Protein Length | 62 Amino acids |
Molecular weight | 7111 |
Domain Name | N/A |
References | 1 PubMed abstract 10407478 |
Hormone | N/A |
Gene ID | N/A |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
HMRbase accession number | 22921 |
Swiss-prot Accession number | Q9XSB4 (Sequence in FASTA format) |
Description | Thyroid hormone receptor beta2; Fragment |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | N/A |
Developmental Stage | N/A |
Similarity | N/A |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | N/A |
Protein Length | 45 Amino acids |
Molecular weight | 5045 |
Domain Name | N/A |
References | 1 PubMed abstract 10407478 |
Hormone | N/A |
Gene ID | N/A |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
HMRbase accession number | 22970 |
Swiss-prot Accession number | Q4W810 (Sequence in FASTA format) |
Description | Transmembrane leptin receptor |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | N/A |
Developmental Stage | N/A |
Similarity | N/A |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | N/A |
Protein Length | 1166 Amino acids |
Molecular weight | 132789 |
Domain Name | fn3 Lep_receptor_Ig |
References | ---- |
Hormone | O02720 Detail in HMRbase |
Gene ID | 450207 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |